Child/Adolescent Anxiety Multimodal Study: Evaluating Safety
Identifieur interne : 003955 ( Main/Exploration ); précédent : 003954; suivant : 003956Child/Adolescent Anxiety Multimodal Study: Evaluating Safety
Auteurs : Moira A. Rynn ; John T. Walkup ; Scott N. Compton ; Dara J. Sakolsky ; Joel T. Sherrill ; Sa Shen ; Philip C. Kendall ; James Mccracken ; Anne Marie Albano ; John Piacentini ; Mark A. Riddle ; Courtney Keeton ; Bruce Waslick ; Allan Chrisman ; Satish Iyengar ; John S. March ; Boris BirmaherSource :
- Journal of the American Academy of Child and Adolescent Psychiatry [ 0890-8567 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Angoisse de la séparation (), Association thérapeutique, Diagnostic and stastistical manual of mental disorders (USA), Enfant, Femelle, Humains, Indice de gravité médicale, Inhibiteurs de la capture de la sérotonine (effets indésirables), Inhibiteurs de la capture de la sérotonine (usage thérapeutique), Modèles logistiques, Mâle, Méthode en double aveugle, Résultat thérapeutique, Sertraline (effets indésirables), Sertraline (usage thérapeutique), Thérapie cognitive, Troubles phobiques (), Échelles d'évaluation en psychiatrie.
- MESH :
- effets indésirables : Inhibiteurs de la capture de la sérotonine, Sertraline.
- usage thérapeutique : Inhibiteurs de la capture de la sérotonine, Sertraline.
- Adolescent, Angoisse de la séparation, Association thérapeutique, Diagnostic and stastistical manual of mental disorders (USA), Enfant, Femelle, Humains, Indice de gravité médicale, Modèles logistiques, Mâle, Méthode en double aveugle, Résultat thérapeutique, Thérapie cognitive, Troubles phobiques, Échelles d'évaluation en psychiatrie.
English descriptors
- KwdEn :
- Adolescent, Anxiety, Separation (therapy), Child, Cognitive Therapy, Combined Modality Therapy, Diagnostic and Statistical Manual of Mental Disorders, Double-Blind Method, Female, Humans, Logistic Models, Male, Phobic Disorders (therapy), Psychiatric Status Rating Scales, Serotonin Uptake Inhibitors (adverse effects), Serotonin Uptake Inhibitors (therapeutic use), Sertraline (adverse effects), Sertraline (therapeutic use), Severity of Illness Index, Treatment Outcome.
- MESH :
- chemical , adverse effects : Serotonin Uptake Inhibitors, Sertraline.
- chemical , therapeutic use : Serotonin Uptake Inhibitors, Sertraline.
- therapy : Anxiety, Separation, Phobic Disorders.
- Adolescent, Child, Cognitive Therapy, Combined Modality Therapy, Diagnostic and Statistical Manual of Mental Disorders, Double-Blind Method, Female, Humans, Logistic Models, Male, Psychiatric Status Rating Scales, Severity of Illness Index, Treatment Outcome.
Abstract
To evaluate the frequency of adverse events (AEs) across four treatment conditions in the Child/Adolescent Anxiety Multimodal Study (CAMS), and to compare the frequency of AEs between children and adolescents.
Participants ages 7-17 years (M=10.7) meeting the
There were no differences between the double-blinded conditions (SRT vs. PBO) for total physical and psychiatric AEs or any individual physical or psychiatric AEs. The rates of total physical AEs were greater in the SRT-alone treatment condition when compared to CBT (p<.01) and COMB (p<.01). Moreover, those who received SRT alone reported higher rates of several physical AEs when compared to COMB and CBT. The rate of total psychiatric AEs was higher in children (≤12 years) across all arms (31.7% vs. 23.1%, p<.05). Total PSC scores decreased over time with no significant differences between treatment groups.
The results support the tolerability/safety of selective serotonin reuptake inhibitor (SSRI) treatment for anxiety disorders even after adjusting for the number of reporting opportunities leading to no differences in overall rates of AEs. Few differences occurred on specific items. Additional monitoring of psychiatric AEs is recommended in children (≤12 years).
Url:
DOI: 10.1016/j.jaac.2014.12.015
PubMed: 25721183
PubMed Central: 4362776
Affiliations:
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Le document en format XML
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Rynn</name></author><author><name sortKey="Walkup, John T" sort="Walkup, John T" uniqKey="Walkup J" first="John T." last="Walkup">John T. Walkup</name></author><author><name sortKey="Compton, Scott N" sort="Compton, Scott N" uniqKey="Compton S" first="Scott N." last="Compton">Scott N. Compton</name></author><author><name sortKey="Sakolsky, Dara J" sort="Sakolsky, Dara J" uniqKey="Sakolsky D" first="Dara J." last="Sakolsky">Dara J. Sakolsky</name></author><author><name sortKey="Sherrill, Joel T" sort="Sherrill, Joel T" uniqKey="Sherrill J" first="Joel T." last="Sherrill">Joel T. Sherrill</name></author><author><name sortKey="Shen, Sa" sort="Shen, Sa" uniqKey="Shen S" first="Sa" last="Shen">Sa Shen</name></author><author><name sortKey="Kendall, Philip C" sort="Kendall, Philip C" uniqKey="Kendall P" first="Philip C." last="Kendall">Philip C. Kendall</name></author><author><name sortKey="Mccracken, James" sort="Mccracken, James" uniqKey="Mccracken J" first="James" last="Mccracken">James Mccracken</name></author><author><name sortKey="Albano, Anne Marie" sort="Albano, Anne Marie" uniqKey="Albano A" first="Anne Marie" last="Albano">Anne Marie Albano</name></author><author><name sortKey="Piacentini, John" sort="Piacentini, John" uniqKey="Piacentini J" first="John" last="Piacentini">John Piacentini</name></author><author><name sortKey="Riddle, Mark A" sort="Riddle, Mark A" uniqKey="Riddle M" first="Mark A." last="Riddle">Mark A. Riddle</name></author><author><name sortKey="Keeton, Courtney" sort="Keeton, Courtney" uniqKey="Keeton C" first="Courtney" last="Keeton">Courtney Keeton</name></author><author><name sortKey="Waslick, Bruce" sort="Waslick, Bruce" uniqKey="Waslick B" first="Bruce" last="Waslick">Bruce Waslick</name></author><author><name sortKey="Chrisman, Allan" sort="Chrisman, Allan" uniqKey="Chrisman A" first="Allan" last="Chrisman">Allan Chrisman</name></author><author><name sortKey="Iyengar, Satish" sort="Iyengar, Satish" uniqKey="Iyengar S" first="Satish" last="Iyengar">Satish Iyengar</name></author><author><name sortKey="March, John S" sort="March, John S" uniqKey="March J" first="John S." last="March">John S. March</name></author><author><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name></author></analytic><series><title level="j">Journal of the American Academy of Child and Adolescent Psychiatry</title><idno type="ISSN">0890-8567</idno><idno type="eISSN">1527-5418</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Anxiety, Separation (therapy)</term><term>Child</term><term>Cognitive Therapy</term><term>Combined Modality Therapy</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Phobic Disorders (therapy)</term><term>Psychiatric Status Rating Scales</term><term>Serotonin Uptake Inhibitors (adverse effects)</term><term>Serotonin Uptake Inhibitors (therapeutic use)</term><term>Sertraline (adverse effects)</term><term>Sertraline (therapeutic use)</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Angoisse de la séparation ()</term><term>Association thérapeutique</term><term>Diagnostic and stastistical manual of mental disorders (USA)</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Inhibiteurs de la capture de la sérotonine (effets indésirables)</term><term>Inhibiteurs de la capture de la sérotonine (usage thérapeutique)</term><term>Modèles logistiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Sertraline (effets indésirables)</term><term>Sertraline (usage thérapeutique)</term><term>Thérapie cognitive</term><term>Troubles phobiques ()</term><term>Échelles d'évaluation en psychiatrie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Serotonin Uptake Inhibitors</term><term>Sertraline</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Serotonin Uptake Inhibitors</term><term>Sertraline</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Inhibiteurs de la capture de la sérotonine</term><term>Sertraline</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Anxiety, Separation</term><term>Phobic Disorders</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Inhibiteurs de la capture de la sérotonine</term><term>Sertraline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child</term><term>Cognitive Therapy</term><term>Combined Modality Therapy</term><term>Diagnostic and Statistical Manual of Mental Disorders</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Psychiatric Status Rating Scales</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Angoisse de la séparation</term><term>Association thérapeutique</term><term>Diagnostic and stastistical manual of mental disorders (USA)</term><term>Enfant</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Modèles logistiques</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>Thérapie cognitive</term><term>Troubles phobiques</term><term>Échelles d'évaluation en psychiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To evaluate the frequency of adverse events (AEs) across four treatment conditions in the Child/Adolescent Anxiety Multimodal Study (CAMS), and to compare the frequency of AEs between children and adolescents.</p></sec><sec id="S2"><title>Method</title><p id="P2">Participants ages 7-17 years (M=10.7) meeting the <italic>DSM-IV</italic> criteria for one or more of the following disorders: separation anxiety disorder, generalized anxiety disorder, or social phobia were randomized (2:2:2:1) to cognitive-behavioral therapy (CBT, n=139), sertraline (SRT, n=133), combination of both (COMB, n=140), or pill placebo (PBO, n=76). AEs were collected via a standardized inquiry method plus a self-report Physical Symptom Checklist (PSC).</p></sec><sec id="S3"><title>Results</title><p id="P3">There were no differences between the double-blinded conditions (SRT vs. PBO) for total physical and psychiatric AEs or any individual physical or psychiatric AEs. The rates of total physical AEs were greater in the SRT-alone treatment condition when compared to CBT (p<.01) and COMB (p<.01). Moreover, those who received SRT alone reported higher rates of several physical AEs when compared to COMB and CBT. The rate of total psychiatric AEs was higher in children (≤12 years) across all arms (31.7% vs. 23.1%, p<.05). Total PSC scores decreased over time with no significant differences between treatment groups.</p></sec><sec id="S4"><title>Conclusion</title><p id="P4">The results support the tolerability/safety of selective serotonin reuptake inhibitor (SSRI) treatment for anxiety disorders even after adjusting for the number of reporting opportunities leading to no differences in overall rates of AEs. Few differences occurred on specific items. Additional monitoring of psychiatric AEs is recommended in children (≤12 years).</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Albano, Anne Marie" sort="Albano, Anne Marie" uniqKey="Albano A" first="Anne Marie" last="Albano">Anne Marie Albano</name><name sortKey="Birmaher, Boris" sort="Birmaher, Boris" uniqKey="Birmaher B" first="Boris" last="Birmaher">Boris Birmaher</name><name sortKey="Chrisman, Allan" sort="Chrisman, Allan" uniqKey="Chrisman A" first="Allan" last="Chrisman">Allan Chrisman</name><name sortKey="Compton, Scott N" sort="Compton, Scott N" uniqKey="Compton S" first="Scott N." last="Compton">Scott N. Compton</name><name sortKey="Iyengar, Satish" sort="Iyengar, Satish" uniqKey="Iyengar S" first="Satish" last="Iyengar">Satish Iyengar</name><name sortKey="Keeton, Courtney" sort="Keeton, Courtney" uniqKey="Keeton C" first="Courtney" last="Keeton">Courtney Keeton</name><name sortKey="Kendall, Philip C" sort="Kendall, Philip C" uniqKey="Kendall P" first="Philip C." last="Kendall">Philip C. Kendall</name><name sortKey="March, John S" sort="March, John S" uniqKey="March J" first="John S." last="March">John S. March</name><name sortKey="Mccracken, James" sort="Mccracken, James" uniqKey="Mccracken J" first="James" last="Mccracken">James Mccracken</name><name sortKey="Piacentini, John" sort="Piacentini, John" uniqKey="Piacentini J" first="John" last="Piacentini">John Piacentini</name><name sortKey="Riddle, Mark A" sort="Riddle, Mark A" uniqKey="Riddle M" first="Mark A." last="Riddle">Mark A. Riddle</name><name sortKey="Rynn, Moira A" sort="Rynn, Moira A" uniqKey="Rynn M" first="Moira A." last="Rynn">Moira A. Rynn</name><name sortKey="Sakolsky, Dara J" sort="Sakolsky, Dara J" uniqKey="Sakolsky D" first="Dara J." last="Sakolsky">Dara J. Sakolsky</name><name sortKey="Shen, Sa" sort="Shen, Sa" uniqKey="Shen S" first="Sa" last="Shen">Sa Shen</name><name sortKey="Sherrill, Joel T" sort="Sherrill, Joel T" uniqKey="Sherrill J" first="Joel T." last="Sherrill">Joel T. Sherrill</name><name sortKey="Walkup, John T" sort="Walkup, John T" uniqKey="Walkup J" first="John T." last="Walkup">John T. Walkup</name><name sortKey="Waslick, Bruce" sort="Waslick, Bruce" uniqKey="Waslick B" first="Bruce" last="Waslick">Bruce Waslick</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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